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Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses

文献类型： 外文期刊

作者： Liu, Chang 3 ; Xin, Ying 1 ; Xu, Le 1 ; Cai, Zhaokui 5 ; Xue, Yuanchao 6 ; Liu, Yong; Xie, Daoxin 1 ; Liu, Yule 1 ; Qi, Y 1 ;

作者机构： 1.Tsinghua Univ, Sch Life Sci, Ctr Plant Biol, Beijing 100084, Peoples R China

2.Tsinghua Peking Ctr Life Sci, Beijing 100084, Peoples R China

3.China Agr Univ, Coll Biol Sci, Beijing 100193, Peoples R China

4.Natl Inst Biol Sci, Beijing 102206, Peoples R China

5.Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China

6.Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol,

期刊名称：DEVELOPMENTAL CELL （ 影响因子：12.27； 五年影响因子：12.332 ）

ISSN： 1534-5807

年卷期： 2018 年 44 卷 3 期

页码：

收录情况： SCI

摘要： Conventional RNA interference (RNAi) pathways suppress eukaryotic gene expression at the transcriptional or post-transcriptional level. At the core of RNAi are small RNAs (sRNAs) and effector Argonaute (AGO) proteins. Arabidopsis AGO1 is known to bind microRNAs (miRNAs) and post-transcriptionally repress target genes in the cytoplasm. Here, we report that AGO1 also binds to the chromatin of active genes and promotes their transcription. We show that sRNAs and SWI/SNF complexes associate with nuclear AGO1 and are required for AGO1 binding to chromatin. Moreover, we show that various stimuli, including plant hormones and stresses, specifically trigger AGO1 binding to stimulus-responsive genes. Finally, we show that AGO1 facilitates the induction of genes in jasmonate (JA) signaling pathways and the activation of JA responses. Our findings suggest that, by binding and facilitating the expression of stimuli-specific genes, AGO1 may regulate diverse signaling pathways and associated biological processes.

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