文献类型： 外文期刊

作者： Li, Rui ¹ ; Yang, Yongfang ¹ ; Lou, Hao ¹ ; Wang, Weicheng ¹ ; Du, Ran ³ ; Chen, Haidong ³ ; Du, Xiaoxi ¹ ; Hu, Shuai ¹ ; Wang, Guo-Liang ² ; Yan, Jianbin ³ ; Shan, Xiaoyi ¹ ; Xie, Daoxin ¹ ;

作者机构： 1.Tsinghua Univ, Tsinghua Peking Joint Ctr Life Sci, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China

2.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China

3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch,Key Lab Synthet Biol Minist Agr &, Guangdong Lab Lingnan Modern Agr, Shenzhen, Peoples R China

4.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Seed Innovat, Beijing 100101, Peoples R China

5.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Biosafety Monitoring & Mol Breeding, Haikou, Peoples R China

6.Chinese Acad Trop Agr Sci, San Ya Res Inst, Haikou, Peoples R China

7.Ohio State Univ, Dept Plant Pathol, Columbus, OH 43210 USA

8.Hunan Acad Agr Sci, Hunan Hybrid Rice Res Ctr, State Key Lab Hybrid Rice, Changsha 410125, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：15.7； 五年影响因子：17.2 ）

ISSN：

年卷期： 2025 年 16 卷 1 期

页码：

收录情况： SCI

摘要： Animals rely on nervous systems to cope with environmental variability, whereas plants are characterized by lack of nervous system but still have evolved systemic communication systems through signaling molecules that trigger long-distance defense signaling events when encountered with environmental challenges. Here, our genetic screening of the previously constructed hairpin RNA-based Arabidopsis library identifies a glutathione (GSH)-deficient mutant that has high accumulation of glutamate (Glu), a previously defined wound signal essential for activating plant defense, but disharmoniously exhibits attenuation of defense signaling events. We further uncover GSH as a critical signaling molecule that relies on GLUTAMATE RECEPTOR-LIKE 3.3 (GLR3.3) to trigger long-distance calcium-based defense signaling events in plants. Our findings offer new insights into highly sophisticated systemic defense systems evolved by plants to defend against herbivory and pathogen invasion.