Improving the prebiotic activity and oxidative stability of carboxymethyl curdlan - quercetin conjugates stabilized Pickering emulsions for the colonic targeting delivery of curcumin
文献类型： 外文期刊
作者： Li, Huan 1 ; He, Wenjiang 2 ; Wang, Zijun 1 ; Zhang, Qun 1 ; Hu, Die 3 ; Ding, Ke 1 ; Xie, Qiutao 1 ; Xu, Yanqun 4 ; Shan, Yang 1 ; Ding, Shenghua 1 ;
作者机构： 1.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Dongting Lab, Hunan Prov Key Lab Fruits & Vegetables Storage Pro, Changsha 410125, Peoples R China
2.Infinitus China Co Ltd, R&D Ctr, Guangzhou 510520, Peoples R China
3.Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China
4.Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310058, Peoples R China
关键词： Pickering emulsions; Curcumin; Quercetin; Carboxymethyl curdlan; Prebiotic activity
期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.0； 五年影响因子：8.5 ）
ISSN： 0963-9969
年卷期： 2025 年 201 卷
页码：
收录情况： SCI
摘要： The carboxymethyl curdlan-quercetin conjugate (CMCD-QUE) was synthesized to stabilize curcumin (CUR) -loaded Pickering emulsions. The physicochemical properties, antioxidant activity, and prebiotic activity of CMCD-QUE were investigated. The effects of different concentrations of CMCD-QUE on CUR-loaded emulsions were also explored. CMCD-QUE exhibited excellent antioxidant activity throughout in vitro simulated gastrointestinal digestion. The particle size and electrostatic repulsion of CMCD-QUE gradually increased with rising pH, indicating that CMCD-QUE was pH-responsive. CMCD-QUE exhibited prebiotic activity and specifically promoted the enrichment of Akkermansia. The droplet size of the CMCD-QUE stabilized emulsions became smaller and more uniform as the carrier concentration increased. A concentration of 5% CMCD-QUE could be stably adsorbed at the oil-water interface of the emulsion, which exhibited a maximum encapsulated efficiency (95.85%) of CUR. CMCD-QUE showed excellent antioxidant capacity, pH responsiveness, and prebiotic activity, making it a promising multifunctional emulsifier for colon-targeted delivery of functional ingredients.
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