Proanthocyanidins isolated from lotus seed skin mitigate glycolipid metabolism disorder through the p38/Nrf2/NF-κB signaling pathway
文献类型： 外文期刊
作者： Yi, Yuhang 1 ; Li, Tao 2 ; Lv, Chenghao 3 ; He, Wenjiang 3 ; Li, Wenzhi 4 ; Zhou, Xixin 3 ; Qin, Si 1 ;
作者机构： 1.Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China
2.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China
3.Hunan Agr Univ, Coll Biol Sci & Technol, Changsha 410128, Peoples R China
4.Infinitus China Co Ltd, Guangzhou 510665, Peoples R China
关键词： proanthocyanidins; lotus seed skin; p38/Nrf2/NF-kappa B; glycolipid metabolism
期刊名称：ACTA BIOCHIMICA ET BIOPHYSICA SINICA （ 影响因子：3.4； 五年影响因子：3.5 ）
ISSN： 1672-9145
年卷期： 2024 年 56 卷 9 期
页码：
收录情况： SCI
摘要： Lotus seed skin extract is rich in flavonoids, making it a promising candidate for developing health products. In a previous study, we found that proanthocyanidins from lotus seed skin, particularly proanthocyanidin B1 (PB1), can indirectly activate the Nrf2 signaling pathway, exerting an antioxidant effect. In this study, we isolate proanthocyanidins from lotus seed skin (PLS) using ethanol extraction and RP-HPLC identification, and investigate its effects on glycolipid metabolism both in vivo and in vitro. Our results demonstrate that PLS reduces body weight in high-fat diet (HFD) mice by decreasing feed efficiency. PLS also normalizes serum glucose, insulin secretion, glycosylated hemoglobin (HbA1c), and intraperitoneal glucose tolerance (IPGTT). Furthermore, PLS significantly improves blood lipid parameters and inhibits the expressions of six proinflammatory factors, including IL-1 alpha, IL-1(3, IL-3, IL-6, IFN-gamma and TNF-alpha in HFD mice. Additionally, analysis of fresh liver tissues reveals that PLS and PB1 induce the expressions of antioxidant proteins such as HO-1 and NQO1 by activating the p38-Nrf2 signaling pathway and inhibiting the NF kappa B signaling pathway. In conclusion, proanthocyanidins from lotus seed skin regulate glycolipid metabolism disorders by targeting the p38/Nrf2/NF-kappa B signaling pathway. Our study offers a new approach for the high-value comprehensive utilization of lotus seed skin by-products and precise dietary intervention for metabolic syndrome.
- 相关文献
作者其他论文 更多>>
-
Sustained Green Manure-Rice Rotations Can Mitigate Methane Emissions by Enhancing Microbial Methane Oxidation in Southern China
作者：Liang, Hao;Fu, Jin;Feng, Jiguang;Zhu, Qiuan;Zhou, Feng;Zhou, Guopeng;Zhou, Guopeng;Cao, Weidong;Smith, Pete;Gabrielle, Benoit;Li, Tao;Schmidt, Susanne;Xu, Changxu;Liu, Jia;Nie, Jun;Wu, Ji;Geng, Mingjian;Wang, Fei;Liang, Yuting;Zhou, Feng
关键词：paddy soil; methane; green manure; rotation year; process-based modeling
-
Improving the prebiotic activity and oxidative stability of carboxymethyl curdlan - quercetin conjugates stabilized Pickering emulsions for the colonic targeting delivery of curcumin
作者：Li, Huan;Wang, Zijun;Zhang, Qun;Ding, Ke;Xie, Qiutao;Shan, Yang;Ding, Shenghua;He, Wenjiang;Hu, Die;Xu, Yanqun
关键词：Pickering emulsions; Curcumin; Quercetin; Carboxymethyl curdlan; Prebiotic activity
-
Extract of Gardenia jasminoides Ellis Attenuates High-Fat Diet-Induced Glycolipid Metabolism Disorder in Rats by Targeting Gut Microbiota and TLR4/Myd88/NF-κB Pathway
作者：Lv, Chenghao;Liu, Xin;Qin, Si;Chen, Shiyun;Yi, Yuhang;Wen, Xinnian;Qin, Si;Li, Tao
关键词：crocin; Gardenia jasminoides Ellis; glycolipid metabolism disorder; gut microbiota; TLR4/Myd88/NF-kappa B pathway
-
Antioxidant Effects and Potential Mechanisms of Citrus reticulata 'Chachi' Components: An Integrated Approach of Network Pharmacology and Metabolomics
作者：Xiao, Jiahao;Shan, Yang;Li, Tao;Pan, Zhaoping;Li, Qili;Fu, Fuhua;Sun, Tian;Jiang, Shengyu;Xiao, Zhiqiang;Shan, Yang;Fu, Fuhua
关键词：Citrus reticulata 'Chachi'; metabolomics; flavonoids; network pharmacology; antioxidant activity
-
Long-term exposure to dietary emulsifier Tween 80 promotes liver lipid accumulation and induces different-grade inflammation in young and aged mice
作者：Li, Tao;Li, Qili;Li, Xiaopeng;Xie, Enjun;Shen, Jie;Chen, Yunmei;Yang, Wanbao;Pan, Quan;Shen, James Zheng;Zhou, Fenghua
关键词：Dietary emulsifiers; Tween 80; Fatty liver; Aged mice; Inflammation
-
The Aqueous Extract of Hemerocallis citrina Baroni Improves the Lactation-Promoting Effect in Bovine Mammary Epithelial Cells through the PI3K-AKT Signaling Pathway
作者：Chen, Jiaxu;Pan, Zhaoping;Li, Qili;Li, Xiaopeng;Wang, Xue;Hao, Dandan;Li, Tao;Fu, Fuhua;Li, Qili;Fu, Fuhua;Wu, Yanyang;Peng, Xiaoyu;Pan, Lina;Li, Wei;Wang, Jiaqi
关键词：flavonoids; Hemerocallis citrina Baroni; hexamethylquercetagetin; lactogenic properties
-
Grafting chlorogenic acid enhanced the antioxidant activity of curdlan oligosaccharides and modulated gut microbiota
作者：Li, Huan;Xu, Saiqing;Ge, Shuai;Xu, Haishan;Shan, Yang;Ding, Shenghua;He, Wenjiang;Xu, Saiqing;Ge, Shuai;Xu, Haishan;Shan, Yang;Ding, Shenghua;Wang, Rongrong
关键词：Chlorogenic acid; Curdlan oligosaccharides; Antioxidant activity; Gut microbiota
