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Long-term exposure to dietary emulsifier Tween 80 promotes liver lipid accumulation and induces different-grade inflammation in young and aged mice

文献类型： 外文期刊

作者： Xie, Enjun 2 ; Chen, Yunmei 3 ; Yang, Wanbao 4 ; Pan, Quan 4 ; Shen, James Zheng 4 ; Zhou, Fenghua 5 ; Shen, Jie 2 ; Li, Tao 1 ; Li, Qili 1 ; Li, Xiaopeng 1 ;

作者机构： 1.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Food Sci & Nutr Ctr, Changsha, Peoples R China

2.Zhejiang Univ, Sch Med, Hangzhou, Peoples R China

3.Xian Med Univ, Sch Pharm, Xian, Peoples R China

4.Texas A&M Univ, Dept Nutr, College Stn, TX USA

5.Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China

关键词： Dietary emulsifiers; Tween 80; Fatty liver; Aged mice; Inflammation

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.1； 五年影响因子：7.7 ）

ISSN： 0963-9969

年卷期： 2024 年 184 卷

页码：

收录情况： SCI

摘要： With the advent of industrialization, there has been a substantial increase in the production and consumption of ultra-processed foods (UPFs). These processed foods often contain artificially synthesized additives, such as emulsifiers. Emulsifiers constitute approximately half of the total amount of food additives, with Tween 80 being a commonly used emulsifier in the food industry. Concurrently, China is undergoing significant demographic changes, transitioning into an aging society. Despite this demographic shift, there is insufficient research on the health implications of food emulsifiers, particularly on the elderly population. In this study, we present novel findings indicating that even at low concentrations, Tween 80 suppressed the viability of multiple cell types. Prolonged in vivo exposure to 1 % Tween 80 in drinking water induced liver lipid accumulation and insulin resistance in young adult mice under a regular chow diet. Intriguingly, in mice with high-fat diet (HFD) induced metabolic dysfunction-associated steatotic liver disease (MASLD), this inductive effect was masked. In aged mice, liver lipid accumulation was replicated under prolonged Tween 80 exposure. We further revealed that Tween 80 induced inflammation in both adult and aged mice, with a more pronounced inflammation in aged mice. In conclusion, our study provides compelling evidence that Tween 80 could contribute to a low-grade inflammation and liver lipid accumulation. These findings underscore the need for increasing attention regarding the consumption of UPFs with Tween 80 as the emulsifier, particularly in the elderly consumers.

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