Gamma-oryzanol prevents ethanol-induced liver injury by ameliorating oxidative stress and modulating apoptosis-related protein expression in mice
文献类型： 外文期刊
作者： Zhu, Lijuan 1 ; Xiang, Siting 1 ; Ou, Zhaoping 1 ; Ma, Chaoyang 1 ; Yi, Xianglian 1 ; Huang, Lin 1 ; Ma, Yurong 1 ; Liang 1 ;
作者机构： 1.Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China
2.Dept Hunan Agr Prod Proc Inst, Changsha 410128, Hunan, Peoples R China
关键词： Gamma-oryzanol; Oxidative stress; Alcohol liver injury; Apoptosis
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2019 年 62 卷
页码：
收录情况： SCI
摘要： Gamma-oryzanol (Orz), a mixture of ferulic acid esters of plant sterols and triterpene alcohols, has been proven to possess multiple activities. The purpose of this study was to explore the hepatoprotective effects and potential mechanisms of Orz against ethanol-induced liver injury in mice. Orz pretreatment significantly reduced the serum levels of ALP, ALT, AST and CYP2E1, and increased the TP and GLB levels in the ethanol-challenged mice. Orz increased the activities of CAT, SOD, GSH-PX and the GSH content in the liver, while decreased hepatic steatosis in ethanol-induced liver injure. Furthermore, Orz significantly decreased the protein expression of ASK1, JNK, P38, active-caspase-9 and active-caspase-3, and the protein ratio of Bax/Bcl-2 in livers of ethanol-challenged mice. These results suggest that Orz provides protection against ethanol-induced liver injury which might be due to its alleviation of oxidative stress and inhibition of apoptosis, possibly inhibiting MAPK signaling pathways mediated mitochondrial signaling pathway activation.
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