Koumine mediates the generation of mtROS through the IP3R1-GRP75-VDAC1 complex to improve Citrinin induced intestinal inflammation
文献类型： 外文期刊
作者： Li, Yuanyuan 1 ; Liu, Xiaofang 1 ; Zhang, Qike 1 ; Jiang, Zonghan 1 ; Zhang, Weiqing 2 ; Yang, Chenglin 1 ; Ni, Jie 1 ; Deng, Siqi 1 ; Yi, Jine 1 ; Wu, Jing 1 ; Sun, Zhiliang 1 ; Liang, Zengenni 2 ; Yuan, Zhihang 1 ;
作者机构： 1.Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China
2.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Dongting Lab, Hunan Prov Key Lab Fruits & Vegetables Storage Pro, Changsha 410125, Peoples R China
3.Yuelushan Lab, Changsha 410128, Peoples R China
关键词： Koumine; Citrinin; Inflammatory bowel disease; Pyroptosis
期刊名称：PHYTOMEDICINE （ 影响因子：8.3； 五年影响因子：8.0 ）
ISSN： 0944-7113
年卷期： 2025 年 142 卷
页码：
收录情况： SCI
摘要： Background: Citrinin (CTN) is a mycotoxin that is difficult to eliminate and easy to ingest. Chronic exposure to CTN can lead to inflammatory bowel disease (IBD). The herb Koumine has strong anti-inflammatory activity and is considered a candidate for the treatment of IBD. Purpose: To investigate the effect of Koumine on IBD induced by CTN exposure and its mechanism of action. Results: This study demonstrated that Koumine effectively attenuates CTN-induced inflammatory damage in the mouse intestine and IPEC-J2 cells. Furthermore, Koumine suppressed CTN-induced upregulation of the IP3R1-GRP75-VDAC1 complex, mitochondrial calcium overload, elevated mitochondrial reactive oxygen species (mtROS) levels, and subsequent pyroptosis. Specific overexpression of mtROS counteracted the therapeutic effect of Koumine on CTN exposure-induced pyroptosis but did not alter mitochondrial calcium levels. Silencing GRP75 ameliorated CTN-induced mitochondrial calcium overload and pyroptosis. Notably, siGRP75 addition did not further enhance the therapeutic effect of Koumine. Conclusions: Koumine ameliorates CTN-induced intestinal inflammation by mediating mtROS production via the IP3R1-GRP75-VDAC1 complex. Koumine is a potential agent for the treatment of intestinal inflammation induced by mycotoxin exposure such as CTN.
- 相关文献
作者其他论文 更多>>
-
Melatonin Alleviates T-2 Toxin-Induced Intestinal Injury by Enhancing Gut Barrier Function and Modulating Microbiota in Weaned Piglets
作者：Wu, You;Xiao, Wenguang;Xiao, Bo;Wang, Yongkang;Li, Yuanyuan;Wu, Aoao;Zhang, Qike;Liu, Xiaofang;Liu, Shuiping;Yuan, Zhihang;Yi, Jine;Wu, Jing;Liang, Zengenni
关键词：melatonin; T-2 toxin; gut barrier function; gut microbiota; SCFAs
-
Killing of colistin-resistant Aeromonas hydrophila by a synthetic peptide
作者：Sun, Leisheng;Li, Dingding;Sun, Leisheng;Jiang, Zonghan;Sun, Zhiliang;Tian, Yao;Liu, Junqi
关键词：
Aeromonas hydrophila ; antimicrobial agents; drug resistance -
Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress
作者：Li, Yuanyuan;Zhang, Qike;Liu, Xiaofang;Wang, Yongkang;Yang, Chenglin;Wu, You;Xiao, Bo;Feng, Yiya;Wu, Aoao;Yi, Jine;Wu, Jing;Yuan, Zhihang;Wu, Jing;Yuan, Zhihang;Liang, Zengenni;Liang, Zengenni
关键词：citrinin; MAM; pyroptosis; mitochondrial oxidative stress; intestinal
-
Melatonin alleviates T-2 toxin-induced oxidative damage, inflammatory response, and apoptosis in piglet spleen and thymus
作者：Ning, Can;Xiao, Wenguang;Wu, You;Fan, Hui;Wang, Siqi;Kong, Xiangyi;Wang, Yongkang;Wu, Aoao;Li, Yuanyuan;Yuan, Zhihang;Wu, Jing;Yang, Chenglin;Liang, Zengenni;Liang, Zengenni
关键词：T-2 toxin; Melatonin; Spleen; Thymus; Immunotoxicity
-
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier
作者：Li, Yuanyuan;Wang, Yongkang;Jiang, Zonghan;Yang, Chenglin;Wu, You;Wu, Aoao;Zhang, Qike;Liu, Xiaofang;Xiao, Bo;Feng, Yiya;Wu, Jing;Yuan, Zhihang;Liang, Zengenni;Wu, Jing;Yuan, Zhihang;Liang, Zengenni
关键词：Citrinin; MAM; Intestinal; Intestinal barrier; Intestinal microbiota; Apoptpsis
-
Koumine inhibits IL-1β-induced chondrocyte inflammation and ameliorates extracellular matrix degradation in osteoarthritic cartilage through activation of PINK1/Parkin-mediated mitochondrial autophagy
作者：Kong, Xiangyi;Ning, Can;Yang, Chenglin;Wu, You;Li, Yuanyuan;Wu, Aoao;Wang, Yongkang;Wang, Siqi;Fan, Hui;Xiao, Wenguang;Wu, Jing;Yuan, Zhihang;Liang, Zengenni;Sun, Zhiliang
关键词：Koumine; Osteoarthritis; Extracellular matrix; Mitophagy; PINK1/Parkin
-
Viola yedoensis Makino alleviates heat stress-induced inflammation, oxidative stress, and cell apoptosis in the spleen and thymus of broilers
作者：Mao, Yan;Kong, Xiangyi;Yang, Chenglin;Wang, Siqi;Fan, Hui;Ning, Can;Xiao, Wenguang;Wu, You;Wu, Jing;Yuan, Zhihang;Liang, Zengenni;Yuan, Liyun
关键词：Viola yedoensis Makino; Heat stress; Broiler; Apoptosis; Oxidative stress; Immune organs
