Anti-obesity mechanism of Ganpu tea revealed by microbiome, metabolome and transcriptome analyses
文献类型： 外文期刊
作者： Liao, Yanfang 1 ; Wang, Chen 1 ; Gao, Zhipeng 3 ; Pan, Zhaoping 2 ; Peng, Mingfang 1 ; Ma, Jie 3 ; Qian, Yujiao 1 ; Guo, Jiajing 2 ; Fu, Fuhua 1 ;
作者机构： 1.Hunan Univ, Coll Biol, Longping Branch, Changsha 410125, Peoples R China
2.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Int Joint Lab Fruits &Vegetables Proc, Hunan Key Lab Fruits & Vegetables Storage, Changsha 410125, Peoples R China
3.Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China
关键词： Ganpu tea; Obesity; Microbiome; Metabolome; Transcriptome
期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）
ISSN： 0308-8146
年卷期： 2023 年 412 卷
页码：
收录情况： SCI
摘要： In this study, the anti-obesity mechanism of Ganpu tea (GPT) from the perspectives of microbiome, metabolome and transcriptome was investigated. GPT significantly reduced the high-fat-diet (HFD)-induced levels of inflammatory cytokines and the expansion of lipid droplets and white adipose tissue. GPT also improved HFDinduced gut microbiome imbalance by significantly reducing the proportion of Firmicutes to Bacteroidota. Metabolomic data showed that HFD-induced metabolic disorder was regulated by GPT and probably characterised by being related to 4-aminobutyraldehyde and 5-acetylamino-6-amino-3-methyluracil. Transcriptome showed that the improvement of obesity was mainly related to the IL-17 signaling pathway and the metabolism of xenobiotics by cytochrome P450. Spearman's correlation analysis indicated that gut microbiota were significantly correlated with inflammatory factors, genes and metabolites. Metabolome-transcriptome analysis showed that GPT reversed obesity mainly through the carbohydrate metabolism, amino acid metabolism and lipid metabolism. Collectively, GPT may be used as a health drink to prevent or treat obesity.
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