文献类型： 会议论文

第一作者： P. Christopoulos

作者： P. Christopoulos ¹ ; G. Mastorakos ¹ ; M. Gazouli ¹ ; E.Deligeoroglou ¹ ; I. Katsikis ² ; E. Diamanti-Kandarakis ³ ; D. Panidis ² ; G. Creatsas ¹ ;

作者机构： 1.Division of Pediatric-Adolescent Gynecology and Reconstructive Surgery, Second Department of Obstetrics and Gynecology, University of Athens, Medical School, Aretaieion Hospital, Athens, Greece

2.Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

3.First Department of Internal Medicine, Endocrine section, University of Athens Medical School, Athens, Greece

关键词： PPAR-γ;PPAR-δ;gene;polymorphism;PCOS;hormones

会议名称： Athens Congress on Women's Health and Disease

主办单位：

页码： 185-191

摘要： The aim of the study was to examine the frequency and relationship of peroxisome proliferator-activated receptor (PPAR)-y and PPAR-b gene polymorphisms to polycystic ovary syndrome (PCOS) characteristics. We conducted a case-control study protocol, which included 183 PCOS women and 148 healthy volunteers. Genetic, clinical, hormonal, and metabolic characteristics of PCOS patients and controls were estimated and compared. Genotype and allele frequencies did not differ significantly. The Pro~(12)Ala polymorphism in exon 2 of the PPAR-y gene was found in low frequency. Regarding the polymorphism in exon 6, the T-allele carrier PCOS women had significantly lower total testosterone levels. Regarding the +294T/C polymorphism in the exon 4 of the PPAR-δ gene, the C-allele carrier PCOS women had significantly higher fasting glucose levels. In conclusion, the PPAR-y gene polymorphisms do not appear to affect the risk for PCOS, except for the reduced testosterone levels. The +294T/C polymorphism in the exon 4 of the PPAR-δ gene seems to cause an increase in fasting glucose levels.

分类号： R173-532