Koumine Attenuates Lipopolysaccaride-Stimulated Inflammation in RAW264.7 Macrophages, Coincidentally Associated with Inhibition of NF-kappa B, ERK and p38 Pathways
文献类型： 外文期刊
作者： Yuan, Zhihang 2 ; Matias, Froilan Bernard 3 ; Wu, Jing 1 ; Liang, Zengenni 4 ; Sun, Zhiliang 1 ;
作者机构： 1.Hunan Agr Univ, Coll Vet Med, Dept Clin Vet Med, Changsha 410128, Hunan, Peoples R China
2.Hunan Coinnovat Ctr Utilizat Bot Funct Ingredient, Changsha 410128, Hunan, Peoples R China
3.Cent Luzon State Univ, Dept Anim Management, Coll Vet Sci & Med, Sci City Of Munoz 3120, Nueva Ecija, Philippines
4.Dept Hunan Agr Prod Proc Inst, Changsha 410128, Hunan, Peoples R China
关键词： inflammation;LPS;NO;koumine;NF-kappa B;RAW264.7 macrophages;iNOS
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）
ISSN： 1422-0067
年卷期： 2016 年 17 卷 3 期
页码：
收录情况： SCI
摘要： Medicinal herbal plants have been commonly used for intervention of different diseases and health enhancement worldwide. Koumine, an alkaloid monomer found abundantly in Gelsemium plants, can be effectively used as an anti-inflammatory medication. In this study, the mechanisms associated with the preventative effect of koumine on lipopolysaccharide (LPS)-mediated inflammation in RAW264.7 macrophages were investigated. Koumine induced a decrease in the level of inducible nitric oxide synthase (iNOS) protein, concomitant reduction in the production of nitric oxide (NO) and reduction of the levels of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-alpha) and IL-1 beta. Furthermore, koumine decreased the phosphorylation of p65 and inhibited nuclear factor kappa B alpha (I kappa B alpha) proteins, resulting in lower production of nuclear factor (NF)-kappa B transactivation. Koumine also induced a decrease in the phosphorylation of extracellular-signal-regulated kinases (ERK) and p38 in RAW264 cells. In conclusion, these findings reveal that koumine decreases the productions of pro-inflammatory mediators though the suppression of p38 and ERK MAPK phosphorylation and the inhibition of NF-kappa B activation in RAW264.7 cells.
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