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Rhein exhibits antioxidative effects similar to Rhubarb in a rat model of traumatic brain injury

文献类型： 外文期刊

作者： Xu, Xia 1 ; Lv, Huiying 2 ; Xia, Zian 1 ; Fan, Rong 1 ; Zhang, Chunhu 1 ; Wang, Yang 1 ; Wang, Dongsheng 1 ;

作者机构： 1.Ctr South Univ, Inst Integrad Tradit Chinese & Western Med, Lab Ethnopharmacol, Changsha 410008, Peoples R China

2.Hunan Acad Agr Sci, Hunan Agr Product Processing Inst, Hunan Food Test & Analys Ctr, Changsha 410125, Peoples R China

关键词： Rhein;Rhubarb;Traumatic brain injury;Oxidative stress;Neuroprotective effect

期刊名称：BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE （ 影响因子：3.659； 五年影响因子：3.767 ）

ISSN： 1472-6882

年卷期： 2017 年 17 卷

页码：

收录情况： SCI

摘要： Background: The brain is secondarily harmed by pathological, physiological, and biological reactions that are caused by traumatic brain injury (TBI). Rhein, a significant composition of Rhubarb, is a well-known traditional Chinese treatment method and has a strong oxidation-resisting characteristic, but Rhein's mechanism remains unclear. Methods: This study aimed to identify Rhein in the brain tissues of TBI model of rats, and confirm whether Rhein induced an antioxidative effect similar to its parent medicine, Rhubarb. First, the ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was applied to identify Rhein in the brain tissue of the controlled cortical impact (CCI) rats after intra-gastric administration of Rhubarb. Further, for the purpose of calculating the oxidant stress of the CCI rats, the malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione disulfide (GSSG), as well as the proportion of glutathione (GSH)/GSSG were measured in the brain tissues. Results: The results showed that Rhein was absorbed in the brain tissues of CCI rats. Rhubarb and rhein elevated the SOD, CAT activities, GSH level, and GSH/GSSG ratio, and diminished the MDA and GSSG levels. Conclusion: The data demonstrated that Rhubarb and Rhein had the potential to be used as a neuroprotective drug for TBI, and that Rhein induced an antioxidative effect similar to its parent medicine, Rhubarb.

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