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The Effects of Warfarin on the Pharmacokinetics of Senkyunolide I in a Rat Model of Biliary Drainage After Administration of Chuanxiong

文献类型： 外文期刊

作者： Li, Haigang 2 ; Jiang, Yu 3 ; Wang, Yang 2 ; Lv, Huiying 4 ; Xie, Haitang 5 ; Yang, Guoping 6 ; Guo, Chengxian 6 ; Tang, 1 ;

作者机构： 1.Changsha Med Univ, Dept Pharm, Changsha, Hunan, Peoples R China

2.Cent S Univ, Xiangya Hosp, Inst Integrat Chinese Med, Changsha, Hunan, Peoples R China

3.Xinjiang Med Univ, Affiliated Hosp TCM, Dept Gerontol, Urumqi, Peoples R China

4.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha, Hunan, Peoples R China

5.Wannan Med Coll, Affiliated Hosp 1, Anhui Prov Ctr Drug Clin Evaluat, Wuhu, Peoples R China

6.Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha, Hunan, Peoples R China

关键词： senkyunolide I; Chuanxiong; warfarin; pharmacokinetics; UPLC-MS/MS; biliary drainage

期刊名称：FRONTIERS IN PHARMACOLOGY （ 影响因子：5.81； 五年影响因子：6.005 ）

ISSN： 1663-9812

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： The aim of this study was to elucidate the effects of warfarin on senkyunolide I in a rat model of biliary drainage after oral administration Chuanxiong extract based on pharmacokinetics. Thirty-two rats were randomly divided into four groups: CN, healthy rats after a single administration of Chuanxiong; CO, rats with biliary drainage after a single administration of Chuanxiong; WCN, healthy rats after the administration of Chuanxiong and warfarin; WCO, rats with biliary drainage after the administration of Chuanxiong and warfarin. A series of blood samples were collected at different time points before and after oral administration. An ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method for quantification of the main components of Chuanxiong and methyclothiazide (internal standard) have been established. The validated method was successfully applied to a comparative pharmacokinetics study. After calculated by the DAS 2.1.1 software, the pharmacokinetics parameters of senkyunolide I showed a significant difference between the CN and CO groups, the AUC(0-t), and C-max of CO group increased by 5.45, 4.02 folds, respectively. There was a significant difference between the WCO and WCN groups, the T-max of WCO group prolonged 67%; compared to the CN group, the AUC(0-t), and Cmax of WCN group raised 4.84, 3.49 folds, respectively; the Tmax and Cmax between the CO and WCO groups also showed a significant difference. The drug warfarin significantly affected the senkyunolide I disposition, which partly due to its enterohepatic circulation process in rat plasma after oral administration of Chuanxiong. The present study highlights an urgent evidence for drug-herb interactions.

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