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Oryzanol Ameliorates DSS-Stimulated Gut Barrier Damage via Targeting the Gut Microbiota Accompanied by the TLR4/NF-?B/ NLRP3 Cascade Response In Vivo

文献类型： 外文期刊

作者： Xia, Xinxin 1 ; Lin, Hai 2 ; Luo, Feijun 1 ; Wu, Xiuxiu 1 ; Zhu, Lingfeng 1 ; Chen, Shuilian 2 ; Luo, Han 1 ; Ye, Fan 1 ; Peng, Xia 2 ; Zhang, Yan 2 ; Yang, Guliang 1 ; Lin, Qinlu 1 ;

作者机构： 1.Cent South Univ Forestry & Technol, Natl Res Ctr Rice Deep Proc & Byprod, Hunan Key Lab Grain oil Deep Proc & Qual Control, Hunan Key Lab Forestry Edible Resources Safety & P, Changsha 410004, Hunan, Peoples R China

2.Yiyang Testing Inst Prod & Commod Qual Supervis, Natl Ctr Dark Tea Prod Qual Inspect &Testing Hunan, Yiyang 413000, Hunan, Peoples R China

3.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410004, Hunan, Peoples R China

关键词： oryzanol; colitis; gut barrier; gut microbiota; SCFAs; TLR4; NF-KB; NLRP3

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.895； 五年影响因子：6.048 ）

ISSN： 0021-8561

年卷期：

页码：

收录情况： SCI

摘要： Inflammatory bowel disease (IBD) is a global chronic disease with a long duration and repeated relapse. Currently, there is still a lack of effective approaches to prevent IBD. Food-derived oryzanol (ORY) possesses extensive biological activities, such as ameliorating bowel diseases, antioxidation, and antiobesity. However, the mechanism of ORY in preventing colitis remains unclear. The present research aims to explore the potential mechanism of ORY in dextran sulfate sodium (DSS)-stimulated colitis in a rat model. The results showed that the symptoms of colitis were significantly improved with the administration of ORY. Mechanismly, the expression levels of Zonula occludens-1 (ZO-1), Claudin-1, Occludin, MUC2, and TFF3 were elevated through ORY treatment, suggesting that oral ORY relieved the degree of gut barrier damage of colitis rats. Meanwhile, 16S sequencing results found that ORY supplementation increased the abundances of Alloprevotella, Roseburia, Treponema, Muribaculaceae, and Ruminococcus, which are associated with the synthesis of short-chain fatty acids (SCFAs). Moreover, GC-MS results confirmed that ORY supplementation reversed the DSS-induced reduction of acetic acid, butyric acid, and total acid. Further research indicated that ORY intervention downregulated the TLR4/NF-KB/NLRP3 pathway, which is closely linked to the expression of proinflammatory cytokines and colon injury. Taken together, ORY ameliorates DSS-stimulated gut barrier damage and inflammatory responses via the gut microbiota-TLR4/NF-KB/NLRP3 signaling axis.

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