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RALF1-FERONIA complex affects splicing dynamics to modulate stress responses and growth in plants

文献类型： 外文期刊

作者： Wang, Long 1 ; Yang, Tao 1 ; Wang, Bingqian 2 ; Lin, Qinlu 1 ; Zhu, Sirui 2 ; Li, Chiyu 2 ; Ma, Youchu 1 ; Tang, Jing 2 ; Xi 1 ;

作者机构： 1.Cent South Univ Forestry & Technol, Natl Engn Lab Rice & By Prod Deep Proc, Changsha 410004, Peoples R China

2.Hunan Univ, Coll Biol, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China

3.Hunan Univ, Hunan Key Lab Plant Funct Genom & Dev Regulat, Changsha 410082, Peoples R China

4.Hunan Hybrid Rice Res Ctr, State Key Lab Hybrid Rice, Changsha 410125, Peoples R China

5.Bielefeld Univ, Fac Biol, RNA Biol & Mol Physiol, D-33615 Bielefeld, Germany

6.Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

期刊名称：SCIENCE ADVANCES （ 影响因子：14.136； 五年影响因子：16.446 ）

ISSN： 2375-2548

年卷期： 2020 年 6 卷 21 期

页码：

收录情况： SCI

摘要： The environmentally responsive signaling pathways that link global transcriptomic changes through alternative splicing (AS) to plant fitness remain unclear. Here, we found that the interaction of the extracellular rapid alkalinization FACTOR 1 (RALF1) peptide with its receptor FERONIA (FER) triggered a rapid and massive RNA AS response by interacting with and phosphorylating glycine-rich RNA binding protein7 (GRP7) to elevate GRP7 nuclear accumulation in Arabidopsis thaliana. FER-dependent GRP7 phosphorylation enhanced its mRNA binding ability and its association with the spliceosome component U1-70K to enable splice site selection, modulating dynamic AS. Genetic reversal of a RALF1-FER-dependent splicing target partly rescued mutants deficient in GRP7. AS of GRP7 itself induced nonsense-mediated decay feedback to the RALF1-FER-GRP7 module, fine-tuning stress responses, and cell growth. The RALF1-FER-GRP7 module provides a paradigm for regulatory mechanisms of RNA splicing in response to external stimuli.

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