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The unfolded protein response and programmed cell death are induced by expression of Garlic virus X p11 in Nicotiana benthamiana

文献类型： 外文期刊

作者： Lu, Yuwen 2 ; Yin, Mingyuan; Wang, Xiaodan; Chen, Binghua; Yang, Xue; Peng, Jiejun 2 ; Zheng, Hongying 2 ; Zh 1 ;

作者机构： 1.Hunan Agr Univ, Coll Plant Protect, Changsha 410128, Hunan, Peoples R China

2.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Sustainable Control P, Key Lab Biotechnol Plant Protect, Hangzhou 310021, Zhejiang, Peoples R China

3.Zhejiang Acad Agr Sci, State Key Lab Breeding Base Sustainable Control P, Key Lab Biotechnol Plant Protect, Ha

期刊名称：JOURNAL OF GENERAL VIROLOGY （ 影响因子：3.891； 五年影响因子：3.719 ）

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收录情况： SCI

摘要： Garlic virus X (GarVX) ORF3 encodes a p11 protein, which contributes to virus cell-to-cell movement and forms granules on the endoplasmic reticulum (ER) in Nicotiana benthamiana. Expression of p11 either from a binary vector, PVX or TMV induced ER stress and the unfolded protein response (UPR), as demonstrated by an increase in transcription of the ER luminal binding protein (BiP) and bZIP60 genes. UPR-related programmed cell death (PCD) was elicited by PVX : p11 or TMV : p11 in systemic infected leaves. Examination of p11 mutants with deletions of two transmembrane domains (TM) revealed that both were required for generating granules and for inducing necrosis. TRV-based VIGS was used to investigate the correlation between bZIP60 expression and p11-induced UPR-related PCD. Less necrosis was observed on local and systemic leaves of bZIP60 knockdown plants when infected with PVXp11, suggesting that bZIP60 plays an important role in the UPR-related PCD response to p11 in N. benthamiana.

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