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Rice black-streaked dwarf virus-encoded P5-1 regulates the ubiquitination activity of SCF E3 ligases and inhibits jasmonate signaling to benefit its infection in rice

文献类型： 外文期刊

作者： He, Long 1 ; Chen, Xuan 1 ; Yang, Jin 1 ; Zhang, Tianye 1 ; Li, Juan 1 ; Zhang, Songbai 6 ; Zhong, Kaili 1 ; Zhang, Hengm 1 ;

作者机构： 1.Ningbo Univ, Inst Plant Virol, State Key Lab Qual & Safety Agroprod, Ningbo 315000, Zhejiang, Peoples R China

2.Nanjing Agr Univ, Coll Plant Protect, Nanjing 21000, Jiangsu, Peoples R China

3.Hunan Agr Univ, Coll Plant Protect, Changsha 410000, Hunan, Peoples R China

4.Zhejiang A&F Univ, Coll Forestry & Biotechnol, Linan 311300, Peoples R China

5.Zhellang Univ, Hangzhou 310021, Zhejiang, Peoples R China

6.Hunan Acad Agr Sci, Inst Plant Protect, Changsha 410000, Hunan, Peoples R China

7.Zhejiang Acad Agr Sci, Inst Virol & Biotechnol, State Key Lab Breeding Base Zhejiang Sustainable, Zhejiang Prov Key Lab Plant Virol, Hangzhou 310021, Zhejiang, Peoples R China

关键词： jasmonic acid pathway; rice; Rice black streaked dwarf virus (RBSDV); SCF complex; ubiquitination

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.151； 五年影响因子：10.475 ）

ISSN： 0028-646X

年卷期：

页码：

收录情况： SCI

摘要： SCF (Skp1/Cullin1/F-box) complexes are key regulators of many cellular processes. Viruses encode specific factors to interfere with or hijack these complexes and ensure their infection in plants. The molecular mechanisms controlling this interference/hijack are currently largely unknown. Here, we present evidence of a novel strategy used by Rice black-streaked dwarf virus (RBSDV) to regulate ubiquitination in rice (Oryza sativa) by interfering in the activity of OsCSN5A. We also show that RBSDV P5-1 specifically affects CSN-mediated deRUBylation of OsCUL1, compromising the integrity of the SCFCOI1 complex. We demonstrate that the expressions of jasmonate (JA) biosynthesis-associated genes are not inhibited, whereas the expressions of JA-responsive genes are down-regulated in transgenic P5-1 plants. More importantly, application of JA to P5-1 transgenic plants did not reduce their susceptibility to RBSDV infection. center dot Our results suggest that P5-1 inhibits the ubiquitination activity of SCF E3 ligases through an interaction with OsCSN5A, and hinders the RUBylation/deRUBylation of CUL1, leading to an inhibition of the JA response pathway and an enhancement of RBSDV infection in rice.

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