Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity
文献类型： 外文期刊
作者： Jia, Yan-Zhe 1 ; Yang, Yu-Pei 1 ; Cheng, Shao-Wu 2 ; Cao, Liang 4 ; Xie, Qing-Ling 1 ; Wang, Meng-Yun 1 ; Li, Bin 1 ; Jia 1 ;
作者机构： 1.Hunan Univ Chinese Med, Sch Pharm, Innovat Mat Med Res Inst, TCM & Ethnomed Innovat & Dev Int Lab, Changsha 410208, Peoples R China
2.Hunan Univ Chinese Med, Key Lab Coll & Univ Hunan Prov Cytobiol & Mol Bio, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China
3.Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China
4.Hunan Acad Agr Sci, Inst Agr Environm & Agroecol, Changsha 410125, Peoples R China
关键词： Kadsura coccinea (Lem.) A. C. Sm.; Schisandraceae; Heilaohu; Phytochemical; Lignans; Hepatoprotective activity; Fruit
期刊名称：PHYTOCHEMISTRY （ 影响因子：3.044； 五年影响因子：3.374 ）
ISSN： 0031-9422
年卷期： 2021 年 184 卷
页码：
收录情况： SCI
摘要： Phytochemical investigations on the fresh fruits of Kadsura coccinea (Lem.) A. C. Sm. have led to the isolation of fourteen undescribed 2,2'-cyclolignans named heilaohuguosus A-N, four undescribed aryltetrahydronaphthalene lignans, heilaohuguosus O-R and one tetrahydrofuran lignan, heilaohuguosu 5, with twenty-seven previously described lignan analogues. Their structures and absolute configurations of heilaohuguosus A S were established by spectroscopic methods including 1D and 2D-NMR techniques and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity against APAP-induced toxicity in HepG 2 cells, four 2,2'-cyclolignans, heilaohuguosus A and L, tiegusanin I and kadsuphilol I showed good hepatopmtective activities against APAP toxicity in HepG 2 cells with cell survival rates of 53.5 +/- 1.7%, 55.2 +/- 1.2%, 52.5 +/- 2.4%, and 54.0 +/- 2.2% (positive control bicyclol, 52.1 +/- 1.3%) at 10 mu M, respectively.
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