New Lead Discovery of Herbicide Safener for Metolachlor Based on a Scaffold-Hopping Strategy
文献类型: 外文期刊
作者: Deng, Xile 1 ; Zheng, Wenna 1 ; Zhan, Qingcai 1 ; Deng, Yanan 1 ; Zhou, Yong 1 ; Bai, Lianyang 1 ;
作者机构: 1.Hunan Acad Agr Sci, Biotechnol Res Inst, Hunan Prov Key Lab Biol & Control Weeds, Changsha 410125, Peoples R China
关键词: sanshools; synthesis; N-alkylamides; natural products; herbicide safener
期刊名称:MOLECULES ( 影响因子:4.411; 五年影响因子:4.587 )
ISSN:
年卷期: 2020 年 25 卷 21 期
页码:
收录情况: SCI
摘要: The use of herbicide safeners can significantly alleviate herbicide injury to protect crop plants and expand the application scope of the existing herbicides in the field. Sanshools, which are well known as spices, are N-alkyl substituted compounds extracted from the Zanthoxylum species and have several essential physiological and pharmacological functions. Sanshools display excellent safener activity for the herbicide metolachlor in rice seedlings. However, the high cost of sanshools extraction and difficulties in the synthesis of their complicated chemical structures limit their utilization in agricultural fields. Thus, the present study designed and synthesized various N-alkyl amide derivatives via the scaffold-hopping strategy to solve the challenge of complicated structures and find novel potential safeners for the herbicide metolachlor. In total, 33 N-alkyl amide derivatives (2a-k, 3a-k, and 4a-k) were synthesized using amines and saturated and unsaturated fatty acids as starting materials through acylation and condensation. The identity of all the target compounds was well confirmed by H-1-NMR, C-13-NMR, and high-resolution mass spectrometry (HRMS). The primary evaluation of safener activities for the compounds by the agar method indicated that most of the target compounds could protect rice seedlings from injury caused by metolachlor. Notably, compounds 2k and 4k displayed excellent herbicide safener activities on plant height and demonstrated relatively similar activities to the commercialized compound dichlormid. Moreover, we showed that compounds 2k and 4k had higher glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and polyphenol oxidase (PPO) activities in rice seedlings, compared to the metolachlor treatment. In particular, 2k and 4k are safer for aquatic organisms than dichlormid. Results from the current work exhibit that compounds 2k and 4k have excellent crop safener activities toward rice and can, thus, be promising candidates for further structural optimization in rice protection.
- 相关文献
作者其他论文 更多>>
-
Self-Assembled Sphere Covalent Organic Framework with Enhanced Herbicidal Activity by Loading Cyhalofop-butyl
作者:Deng, Xile;Bai, Lianyang;Zhao, Pengyue;Xie, Yong
关键词:covalent organic framework; nanopesticide; high loads; enhanced bioactivity; sustainable agriculture
-
Multi-omics analyses reveal the crosstalk between the circadian clock and the response to herbicide application in Oryza sativa
作者:Chen, Ke;Yang, Haona;Peng, Yajun;Wu, Lamei;Zhao, Zhenghong;Bai, Lianyang;Wang, Lifeng;Chen, Ke;Zhao, Zhenghong;Bai, Lianyang;Wang, Lifeng;Chen, Ke;Yang, Haona;Peng, Yajun;Wu, Lamei;Zhao, Zhenghong;Bai, Lianyang;Wang, Lifeng;Su, Xiao;Lin, Tao
关键词:Oryza sativa L; circadian clock; herbicides; RNA-seq; metabolome
-
A MOF-based pH-responsive dual controlled-release system for herbicide pretilachlor and safener AD-67 delivery that enhances the herbicidal efficacy and reduces side effects
作者:Deng, Xile;Peng, Yajun;Bai, Lianyang;Guo, Kunyan;Yang, Ni;Qian, Kun
关键词:
-
Room-temperature ultrasonic-assisted self-assembled synthesis of silkworm cocoon-like COFs@GCNTs composite for sensitive detection of diuron in food samples
作者:Li, Dongdong;Bai, Lianyang;Li, Dongdong;Bai, Lianyang;Li, Dongdong;Zhao, Hongyuan;Wang, Guoquan;Liu, Runqiang
关键词:Diuron; Electrochemical sensor; Synergistic effect; Covalent organic frameworks; Graphitized multi -walled carbon nanotubes
-
Preparation of Thifluzamide Polylactic Acid Glycolic Acid Copolymer Microspheres and Its Effect on the Growth of Cucumber Seedlings
作者:Li, Yuanyuan;Wang, Chaojie;Cai, Runze;Cao, Lidong;Cao, Chong;Zheng, Li;Zhao, Pengyue;Huang, Qiliang;Deng, Xile
关键词:polylactic acid-glycolic acid copolymer; thifluzamide; microspheres; fungicide delivery; cucumber growth
-
Formulation of Matrine Oil-Based Suspension Concentrate for Improving the Wetting of Droplets and Spraying Performance
作者:Li, Meng;Wang, Zhen;Meng, Huanwen;Dong, Baozhu;Zhou, Hongyou;Deng, Xile
关键词:matrine; oil-based suspension concentrate; emulsifier; formulation; wettability; spray performance
-
Knockout of tyramine receptor 1 results in a decrease of oviposition, mating, and sex pheromone biosynthesis in female Plutella xylostella
作者:Zheng, Wei;Liu, Zhangyang;Zhou, Xiaomao;Zheng, Wei;Ma, Haihao;Liu, Zhangyang;Zhou, Yong;Zhu, Hang;Liu, Jia;Zhang, Chengjia;Liu, Zheming;Zhou, Xiaomao;Ma, Haihao;Zhou, Yong;Zhu, Hang;Liu, Jia;Zhang, Chengjia;Liu, Zheming;Zhou, Xiaomao
关键词:tyramine receptor 1; CRISPR; Cas9; oviposition; mating; sex pheromone biosynthesis; Plutella xylostella