The Protective Effects of L-Theanine against Epigallocatechin Gallate-Induced Acute Liver Injury in Mice
文献类型： 外文期刊
作者： Zhu, Kun 1 ; Zeng, Hongzhe 2 ; Yue, Lin 2 ; Huang, Jianan 2 ; Ouyang, Jie 3 ; Liu, Zhonghua 2 ;
作者机构： 1.Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China
2.Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Peoples R China
3.Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China
关键词： L-theanine; EGCG; liver injury; oxidative stress; metabolomics
期刊名称：FOODS （ 影响因子：5.2； 五年影响因子：5.5 ）
ISSN：
年卷期： 2024 年 13 卷 7 期
页码：
收录情况： SCI
摘要： Epigallocatechin-3-gallate (EGCG) is a main bioactive constituent in green tea. Being a redox-active polyphenol, high-dose EGCG exhibits pro-oxidative activity and could cause liver injury. L-theanine is a unique non-protein amino acid in green tea and could provide liver-protective effects. The purpose of this study was to investigate the hepatoprotective effects of L-theanine on EGCG-induced liver injury and the underlying mechanisms. A total of 300 mg/kg L-theanine was administrated to ICR mice for 7 days. Then, the acute liver injury model was established through intragastric administration of 1000 mg/kg EGCG. Pretreatment with L-theanine significantly alleviated the oxidative stress and inflammatory response caused by high-dose EGCG through modulation of Nrf2 signaling and glutathione homeostasis. Furthermore, metabolomic results revealed that L-theanine protects mice from EGCG-induced liver injury mainly through the regulation of amino acid metabolism, especially tryptophan metabolism. These findings could provide valuable insights into the potential therapeutic applications of L-theanine and highlight the importance of the interactions between dietary components.
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