RNA Interference-mediated Knockdown of Several Components of Cytochrome P450 Enzyme Systems, from the Cotton Bollworm,Helicoverpa armigera , Enhances Larval Susceptibility to beta-Cypermethrin
文献类型: 会议论文
第一作者: Tao Tang
作者: Tao Tang 1 ; Chunqing Zhao 2 ; Xiaoyun Feng 2 ; Xueyuan Liu 3 ; Lihong Qiu 2 ;
作者机构: 1.Key Laboratory of Pesticide Chemistry & Application Technology, Ministry of Agriculture, College of Science, China Agricultural University, Beijing, China Institute of Plant Protection, Hunan Academy of Agricultural Sciences,Changsha, China
2.Key Laboratory of Pesticide Chemistry & Application Technology, Ministry of Agriculture, College of Science, China Agricultural University, Beijing, China
3.Institute of Plant Protection, Hunan Academy of Agricultural Sciences,Changsha, China
关键词: Helicoverpa armigera;beta-cypermethrin;cytochrome P450 enzyme systems;insecticide resistance;RNA interference
会议名称: International workshop on crop protection chemistry and regulatory harmonization
主办单位:
页码: 416-417
摘要: @@ The cotton bollworm, Helicoverpa armigera (Hiibner), is an important agricultural pest, making severe yield losses in many crops. Its development of resistance to various agrochemicals has become a serious problem. Previous studies reported that enhanced metabolic activity of cytochrome P450 enzyme systems (P450s) was proved to be a major mechanism of insecticide resistance. Recently, the authors found that knockdown of CYP6B7, cytochrome b5 (Cyt-b5) and NADPH-dependent cytochrome P450 reductase (CPR) in the fenvalerate-resistant HDFR strain of H. armigera by RNA interference (RNAi) via injection of doublestranded RNA (dsRNA), increases larval susceptibility to fenvalerate. In the present study, the functional interactions of CYP6B7, CPR and Cyt-b5 were further assessed using the same strategies and monitoring for resistance levels of beta-cypermethrin.
分类号: s481
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