文献类型： 会议论文

第一作者： Erasmia Kiapekou

作者： Erasmia Kiapekou ¹ ; Evangelia Zapanti ² ; George Mastorakos ³ ; Dimitris Loutradis ¹ ;

作者机构： 1.First Department of Obstetrics and Gynecology, Alexandra Hospital, University of Athens, Athens, Greece

2.First Endocrine Section, Alexandra Hospital, Athens, Greece

3.Endocrine Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Athens, Greece

关键词： CRH;CRH-Rl;ovarian CRH;oocyte maturation

会议名称： Athens Congress on Women's Health and Disease

主办单位：

页码： 225-229

摘要： Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide synthesized by neurons of the parvocellular and paraventricular hypothalamic nuclei. Central CRH is the principal regulator of the stress system influencing several systems in the brain and influenced by them. It activates the secretion of glucocorticoids and indirectly regulates the immune system and the immune response. Peripheral CRH is secreted by postganglionic sympathetic and unmyelinated sensory afferent neurons and has been identified in several peripheral tissues and organs, including those of the reproductive system (ovary, endometrium, placenta, and testis). In the human ovary, receptors are detected in thecal and stromal cells and in follicular fluid. Ovarian CRH regulates ovarian steroidogenesis and is involved in follicular maturation, ovulation, and luteolysis. In this concise review we briefly discuss the role of ovarian CRH in reproduction, emphasizing its role in oocyte maturation.

分类号： R173-532