文献类型： 会议论文

第一作者： N. Vrachnis

作者： N. Vrachnis ¹ ; N. Vitoratos ¹ ; Z. Iliodromiti ¹ ; S. Sifakis ² ; E. Deligeoroglou ¹ ; G.Creatsas ¹ ;

作者机构： 1.Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, Athens, Greece

2.Department of Obstetrics and Gynecology, University Hospital of Heraklio, University of Crete Medical School, Heraklio, Greece

关键词： preterm birth;intrauterine inflammation;fetal viral infection;cerebral palsy;intrauterine death;immunomodulators

会议名称： Athens Congress on Women's Health and Disease

主办单位：

页码： 118-122

摘要： Spontaneous preterm delivery, prematurity, and low birth weight due to prematurity account for a great part of neonatal morbidity and mortality. Specifically, chronic amniotic fluid inflammation may cause preterm labor, with the involvement of different mediators that produce diverse aspects of the inflammatory response. Although bacteria are considered to be the main trigger for intrauterine infection/inflammation, viral infections also appear to be involved. Recently, molecular genetic techniques have helped us better understand the underlying pathophysiologic processes. This is especially important because epidemiological and experimental studies indicate that intrauterine infection and inflammation constitute a risk factor for adverse neurological outcome in preterm infants. Chronic subclinical chorfoamnionitis associated with preterm birth can also modify lung development. Although no current clinical strategy is aimed at adapting the maternofetal inflammatory response, immunomodulators may serve as a future intervention in preterm embryos.

分类号： R173-532