文献类型： 会议论文

第一作者： Ioannis Vamvakas

作者： Ioannis Vamvakas ¹ ; Nefeli Logopati ¹ ; Maria Andreou ¹ ; Marios Sotiropoulos ¹ ; Athanasios Gatzis ¹ ; George Limouris ² ; Christos Antypas ¹ ; Maria Lyra ¹ ;

作者机构： 1.Aretaieion Hospital medical physics department, University of Athens

2.Aretaieion Hospital, University of Athens

关键词： Internal dosimetry;In-111;Planar scintigraphy;Dose calculation

会议名称： International Conference on Information Technology and Applications in Biomedicine (ITAB 2009)

主办单位：

页码： 40-43

摘要： The aim of this study was to calculate the absorbed dose of 22 patients that were diagnosed for neuroendocrine tumours in liver and had received therapeutic dose of ~(111)In octreotide. In-111 Octreotide infusion, via intrahepatic catheterization is well established technique in our Institution in hepatocellular carcinoma and neuroendocrine tumours treatments. The patient specific dosimetry calculations, for this way of treatment, were based on anterior and posterior scintigraphy images that were acquired immediately after radiopharmaceutical infusion, through hepatic arterial port and at 24 and 48 hours post-infusion. Gamma - camera was calibrated in order to estimate source organ activity considering count rate, patient's body diameter and source organ size. The results showed that the tumour absorbed dose ranged from 2.5 to 18.4 mGy/MBq, depending on the lesion size. Patient specific dosimetry calculations helps the physician to optimize the planning of the treatment, avoid side effects to healthy tissue and assign administered dose to treatment results.

分类号： Q811-53