Naturally impaired side-chain shortening of aromatic 3-ketoacyl-CoAs reveals the biosynthetic pathway of plant acetophenones
文献类型： 外文期刊
作者： Zhai, Rui 1 ; Zhang, Hongjuan 1 ; Xie, Yinpeng 1 ; Zhang, Shichao 1 ; Zhou, Fengli 1 ; Du, Xuan 3 ; Chen, Weifeng 4 ; Yan, Yanfang 1 ; Zhang, Jing 1 ; Li, Pengmin 1 ; Atkinson, Ross 5 ; Wang, Zhigang 1 ; Yang, Chengquan 1 ; Guan, Qingmei 1 ; Ma, Fengwang 1 ; Xu, Lingfei 1 ;
作者机构： 1.Northwest A&F Univ, Coll Hort, Yangling, Shaanxi, Peoples R China
2.Northwest A&F Univ, State Key Lab Crop Stress Resistance & High Effici, Shaanxi Key Lab Apple, Yangling, Shaanxi, Peoples R China
3.Shenzhen Univ, Coll Life Sci & Oceanog, Guangdong Prov Key Lab Plant Epigenet, Shenzhen, Peoples R China
4.Hunan Acad Agr Sci, Hunan Hort Res Inst, Changsha, Peoples R China
5.New Zealand Inst Plant & Food Res Ltd, Auckland, New Zealand
期刊名称：NATURE PLANTS （ 影响因子：13.6； 五年影响因子：17.0 ）
ISSN： 2055-026X
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Acetophenones, which show scattered distribution across phylogenetically distant plants and fungi, play diverse roles in plant-plant, plant-insect, plant-microbiome and even animal-insect interactions. However, the enzymatic basis of acetophenone biosynthesis in plants remains unknown. Here we elucidate the complete biosynthetic pathway of picein (4-hydroxyacetophenone glucoside) from 4-coumaroyl-CoA using pear (Pyrus) as a study system. We demonstrate that in certain pear cultivars, the acetophenone moiety originates from an impaired side-chain shortening reaction of an aromatic 3-ketoacyl-CoA intermediate, a key step in the beta-oxidative biosynthesis of benzoic acid. This impairment results from a loss-of-function mutation in a peroxisomal 3-ketoacyl-CoA thiolase. The accumulated aromatic 3-ketoacyl-CoA is subsequently hydrolysed by a thioesterase and undergoes spontaneous decarboxylation to yield the acetophenone moiety. This rare metabolic phenomenon highlights that not only neofunctionalization but also loss-of-function mutations can drive diversification in plant secondary metabolism. Forward genetic approaches are powerful to shed light on such 'hidden' or recessive pathways in plants.
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