Discovery of novel amide derivatives as potent quorum sensing inhibitors of Pseudomonas aeruginosa
文献类型： 外文期刊
作者： He, Zhe 1 ; Guan, Ming-Ming 1 ; Xiong, Lan-Tu 1 ; Li, Xuan 1 ; Zeng, Yan 1 ; Deng, Xile 2 ; Herron, Alastair N. 3 ; Cui, Zi-Ning 1 ;
作者机构： 1.South China Agr Univ, Coll Plant Protect, Natl Key Lab Green Pesticide,Integrat Microbiol Re, Guangdong Prov Key Lab Microbial Signals & Dis Con, Guangzhou 510642, Peoples R China
2.Hunan Acad Agr Sci, Hunan Agr Biotechnol Res Inst, Changsha 410125, Peoples R China
3.Gilead Sci Inc, Foster City, CA 94404 USA
关键词： Pseudomonas aeruginosa; Amide derivatives; Quorum sensing inhibitor; Virulence factors
期刊名称：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY （ 影响因子：6.7； 五年影响因子：6.5 ）
ISSN： 0223-5234
年卷期： 2024 年 271 卷
页码：
收录情况： SCI
摘要： With the increasing reports of antibiotic resistance in this species, Pseudomonas aeruginosa is a common human pathogen with important implications for public health. Bacterial quorum sensing (QS) systems are potentially broad and versatile targets for developing new antimicrobial compounds. While previous reports have demonstrated that certain amide compounds can inhibit bacterial growth, there are few reports on the specific inhibitory effects of these compounds on bacterial quorum sensing systems. In this study, thirty-one amide derivatives were synthesized. The results of the biological activity assessment indicated that A9 and B6 could significantly inhibit the expression of lasB , rhlA , and pqsA , effectively reducing several virulence factors regulated by the QS systems of PAO1. Additionally, compound A9 attenuated the pathogenicity of PAO1 to Galleria mellonella larvae. Meanwhile, RT-qPCR, SPR, and molecular docking studies were conducted to explore the mechanism of these compounds, which suggests that compound A9 inhibited the QS systems by binding with LasR and PqsR, especially PqsR. In conclusion, amide derivatives A9 and B6 exhibit promising potential for further development as novel QS inhibitors in P. aeruginosa .
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