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A papain-like cysteine protease-released small signal peptide confers wheat resistance to wheat yellow mosaic virus

文献类型： 外文期刊

作者： Liu, Peng 1 ; Shi, Chaonan 2 ; Liu, Shuang 1 ; Lei, Jiajia 1 ; Lu, Qisen 1 ; Hu, Haichao 1 ; Ren, Yan 2 ; Zhang, Ning 2 ; Sun, Congwei 2 ; Chen, Lu 1 ; Jiang, Yaoyao 1 ; Feng, Lixiao 1 ; Zhang, Tianye 1 ; Zhong, Kaili 1 ; Liu, Jiaqian 1 ; Zhang, Juan 1 ; Zhang, Zhuo 3 ; Sun, Bingjian 2 ; Chen, Jianping 1 ; Tang, Yimiao 4 ; Chen, Feng 2 ; Yang, Jian 1 ;

作者机构： 1.Ningbo Univ, State Key Lab Managing Biot & Chem Threats Qual &, Minist Agr & Rural Affairs China & Zhejiang Prov, Key Lab Biotechnol Plant Protect,Inst Plant Virol, Ningbo 315211, Peoples R China

2.Henan Agr Univ, Agron Coll, CIMMYT China Wheat & Maize Joint Res Ctr, Natl Key Lab Wheat & Maize Crop Sci, Zhengzhou 450046, Peoples R China

3.Hunan Acad Agr Sci, Hunan Plant Protect Inst, Changsha 410125, Peoples R China

4.Beijing Acad Agr & Forestry Sci, Inst Hybrid Wheat, Beijing 100097, Peoples R China

期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）

ISSN：

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Wheat yellow mosaic virus (WYMV), a soil-borne pathogen, poses a serious threat to global wheat production. Here, we identify a WYMV resistance gene, TaRD21A, that belongs to the papain-like cysteine protease family. Through genetic manipulation of TaRD21A expression, we establish its positive role in the regulation of wheat to WYMV resistance. Furthermore, our investigation shows that the TaRD21A-mediated plant antiviral response relies on the release of a small peptide catalyzed by TaRD21A protease activity. To counteract wheat resistance, WYMV-encoded nuclear inclusion protease-a (NIa) suppress TaRD21A activity to promote virus infection. In resistant cultivars, a natural variant of TaRD21A features a alanine to serine substitution and this substitution enables the phosphorylation of Serine, thereby weakening the interaction between NIa and TaRD21A, reinforcing wheat resistance against WYMV. Our study not only unveils a WYMV resistance gene but also offers insights into the intricate mechanisms underpinning resistance against WYMV. Soil-borne wheat yellow mosaic virus (WYMV) poses a serious threat to global wheat production. Here, the authors report that the nuclear inclusion protease-a produced by WYMV interacts with a small peptide catalyzed by TaRD21A protease activity to mediate WYMV resistance through activating MAPK signaling pathway.

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