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Global analysis of sumoylation function reveals novel insights into development and appressorium-mediated infection of the rice blast fungus

文献类型： 外文期刊

作者： Liu, Caiyun 1 ; Li, Zhigang 1 ; Xing, Junjie 3 ; Yang, Jun 2 ; Wang, Zhao 1 ; Zhang, Hong 1 ; Chen, Deng 3 ; Peng, You-Li 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Plant Sci & Technol, Prov Key Lab Plant Pathol Hubei Prov, Wuhan 430070, Hubei, Peoples R China

2.China Agr Univ, Coll Plant Protect, Key Lab Pest Monitoring & Green Management, Minist Agr,State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China

3.Hunan Hybrid Rice Res Ctr, State Key Lab Hybrid Rice, Changsha 410125, Hunan, Peoples R China

关键词： fungal infection; Magnaporthe oryzae; Post-translational modification; septin; small ubiquitin-like modifier (SUMO); sumoylation

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.151； 五年影响因子：10.475 ）

ISSN： 0028-646X

年卷期： 2018 年 219 卷 3 期

页码：

收录情况： SCI

摘要： Protein post-translational modifications play critical roles in cellular processes, development and stress response. The small ubiquitin-like modifier (SUMO) to proteins is one of the essential modifications in eukaryotes, but its function remains largely unknown in plant pathogenic fungi. We present a comprehensive analysis combined with proteomic, molecular and cellular approaches to explore the roles of sumoylation in the model plant fungal pathogen, Magnaporthe oryzae. We found the SUMO pathway plays key roles in colony growth, conidia formation and virulence to the host, as well as cell-cycle-related phenotypes. Sumoylation is also involved in responding to different stresses. Affinity purification identified 940 putative SUMO substrates, many of which were reported to be involved in development, stress response and infection. Interestingly, four septins were also shown to be sumoylated. Mutation of consensus sumoylation sites in each septin all resulted in reduced virulence to the host and dislocation of septins in appressoria. Moreover, sumoylation is also involved in extracellular secretion of different effector proteins. Our study on the functions of sumoylation provides novel insight into development and infection of the rice blast fungus.

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