A novel outer membrane beta-1,6-glucanase is deployed in the predation of fungi by myxobacteria
文献类型： 外文期刊
作者： Li, Zhoukun 1 ; Ye, Xianfeng 1 ; Liu, Muxing 2 ; Xia, Chengyao 1 ; Zhang, Lei 1 ; Luo, Xue 1 ; Wang, Ting 1 ; Chen, Yue 3 ;
作者机构： 1.Nanjing Agr Univ, Key Lab Agr Environm Microbiol, Minist Agr & Rural Affairs, Coll Life Sci, Nanjing 210095, Jiangsu, Peoples R China
2.Nanjing Agr Univ, Coll Plant Protect, Key Lab Monitoring & Management Plant Dis & Insec, Chinese Minist Agr, Nanjing 210095, Jiangsu, Peoples R China
3.Hunan Acad Agr Sci, Inst Plant Protect, Changsha 410125, Hunan, Peoples R China
期刊名称：ISME JOURNAL （ 影响因子：10.302； 五年影响因子：12.284 ）
ISSN： 1751-7362
年卷期： 2019 年 13 卷 9 期
页码：
收录情况： SCI
摘要： Myxobacterial predation on bacteria has been investigated for several decades. However, their predation on fungi has received less attention. Here, we show that a novel outer membrane beta-1,6-glucanase GluM from Corallococcus sp. strain EGB is essential for initial sensing and efficient decomposition of fungi during predation. GluM belongs to an unstudied family of outer membrane beta-barrel proteins with potent specific activity up to 24,000 U/mg, whose homologs extensively exist in myxobacteria. GluM was able to digest fungal cell walls efficiently and restrict Magnaporthe oryzae infection of rice plants. Genetic complementation with gluM restored the fungal predation ability of Myxococcus xanthus CL1001, which was abolished by the disruption of gluM homolog oar. The inability to prey on fungi with cell walls that lack beta-1,6-glucans indicates that beta-1,6-glucans are targeted by GluM. Our results demonstrate that GluM confers myxobacteria with the ability to feed on fungi, and provide new insights for understanding predator-prey interactions. Considering the attack mode of GluM, we suggest that beta-1,6-glucan is a promising target for the development of novel broad-spectrum antifungal agents.
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