An ultra high performance liquid chromatography with tandem mass spectrometry method for plasma and cerebrospinal fluid pharmacokinetics of rhein in patients with traumatic brain injury after administration of rhubarb decoction

Fan, Rong; Luo, Jiekun; Tang, Tao; Xing, Zhihua; Xia, Zian; Peng, Weijun; Wang, Wenzhu; Huang, Wei; Huang, Xi; Wang, Wenzhu; Wang, Wenzhu; Lv, Huiying; Liang, Yizeng; Lu, Hongmei; Yi, Lunzhao; SCI

机构： Cent S Univ, Xiangya Hosp, Lab Ethnopharmacol, Inst Integrated Tradit Chinese & Western Med, Changsha 410008, Hunan, Peoples R China; Cent S Univ, Xiangya Hosp, Lab Ethnopharmacol, Inst Integrated Tradit Chinese & Wester;

关键词： Blood-brain barrier Pharmacokinetics Rhubarb Traumatic brain injury Ultra high performance liquid chromatography with tandem mass spectrometry